XO Skin Health Complexion Clarifying Serum


A water-based serum engineered with ZO® sebum-targeting science, clinically proven to reduce surface oil, congestion + visible redness for a continually clear + balanced complexion.



This foundational staple is formulated for a range of skin types, especially combination, oily + blemish-prone skin.

Fragrance- and alcohol-free.


  • Proven to decongest skin + reduce shine in 2 weeks.
  • Minimizes excess sebum with daily use, while providing optimal hydration for a range of skin types.
  • Reduces visible redness for a more uniform complexion.
  • Light, water-gel formula layers easily.
  • Features a unique dropper that fills automatically for ease of application.



Apply to clean, dry skin morning and night.


Key Ingredients


  • ZO® Sebum Targeting Complex (Eugenia uniflora leaf extract, Syringa vulgaris extract, Rosa Canina extract)
  • Minimizes excess surface sebum and helps promote a balanced microbiome for a clear + shine-free complexion
  • Water-Soluble Salicylic Acid
  • Powerfully decongests skin + refines the look of pores in a gentle, non-drying delivery
  • ZO-RRS2®
  • Exclusive plant stem cell complex that soothes visible redness while neutralizing damaging free radicals
  • ZPOLY™
  • Exclusive plant-derived polysaccharide complex that supports skin’s protective barrier + helps minimize signs of premature skin aging


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